I'd try D3, but I haven't looked into it (like Bart). Plus I don't really like pointy/clicky games much (unless I can use my ps3 controller, in which case I'd be interested).
Also i never played a Diablo game before and don't want to jump into D3 and be like "lol I have no idea what I'm doing or what's going on in the story"
It looks good. But I don't like the fact of must be on the internet to play it. (Or as it seems from what I've been reading) Cuz my ISP sucks balls and I get dropped connections a lot (mostly at night).
It's similar to FFXI in that you run the game from hard disk but all your character data etc is stored via server and requires you to login each time to play. I still don't get what Blizzard are trying to do with this stupid system but oh well.